CD55 may be an important prognostic factor of thymic epithelial tumors: a retrospective study.

ABSTRACT:

Background

Thymic epithelial tumors (TETs) currently lack effective prognostic factors and novel treatment approaches, the aim of the study is to investigate the expression of CD55 in TETs and the relationship with clinicopathological characteristics and prognosis.

Methods

Firstly, 250 TETs, including 206 thymoma and 44 thymic squamous cell carcinomas (TSCC), were retrospectively selected. Subsequently, the expression levels of CD55 protein and mRNA were assessed using immunohistochemistry (IHC) and qRT-PCR. Finally, the relationship among CD55, clinicopathological characteristics, and prognosis was analyzed.

Results

The expression of CD55 mRNA and protein were higher in thymoma (p = 0.0148; p < 0.0001) and TSCC (both p < 0.0001) compared with normal thymus tissues. I

SUBMITTER: Ma J 

PROVIDER: S-EPMC12542390 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature