Impact of clinical factors and season on inflammatory cytokines in biologic-treated and untreated asthma.

ABSTRACT:

Background

Clinical features influence cytokine profiles and can inform biomarker studies.

Objectives

We assessed the impact of 13 preselected patient characteristics on the circulating levels of 15 Th-1/2/17 cytokines in moderate-to-severe asthma patients on omalizumab, anti-IL-5 (mepolizumab, benralizumab), or dupilumab (n = 76) versus controls (n = 162) not yet on biologics but meeting eligibility criteria for a T2-biologic.

Methods

Plasma cytokines (Olink) were analyzed for associations with these clinical/lifestyle factors using LASSO regression and observed variance explained estimated using generalized linear models. Differential expression analysis was conducted using limma.

Results

In controls, IL-6 had the highest variance explained by clinical/lifest

SUBMITTER: Nopsopon T 

PROVIDER: S-EPMC12542395 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature