Novel proteomic characterization of multiple myeloma bone marrow interstitial fluid links prognosis to coagulation pathways.

ABSTRACT:

Background

Multiple myeloma (MM), the second most prevalent hematological malignancy, carries high morbidity with variability in clinical progression among patients. This necessitates accurate risk stratification for effective therapy and life planning. While extensively genomically and transcriptomically characterized, MM remains modestly studied from a proteomic perspective. As proteomics is a closer measure of phenotype than genomic and transcriptomic assessments, addressing this gap in the literature may yield new insights into disease biology and novel biomarkers.

Methods

Herein, we applied a new sample preparation approach for mass-spectrometry based proteomics to bone marrow interstitial fluid (BMIF) from patients with MM or its precursors.

Results

We achieved

SUBMITTER: Cutler S 

PROVIDER: S-EPMC12542439 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature