Effect of different targeted tidal volumes during high-frequency oscillation with volume-targeted ventilation on cerebral blood flow velocity and cardiac output: study protocol for a randomised crossover study.

ABSTRACT:

Background

High frequency oscillation (HFO) is a lung protective ventilation strategy for newborn infants due to the small tidal volume delivery at fast frequencies, but has been associated with an increased risk of brain injury. High-frequency oscillation with volume-targeted ventilation (HFO&VTV) is a new mode of HFO that applies a targeted tidal volume (VThf) set by the clinician and achieves less fluctuations of carbon dioxide levels and therefore reduces the risk of brain injury. The optimal starting VThf values, however, have not been explored to date. This study investigates the optimum starting settings in newborn infants receiving HFO by comparing the cerebral blood flow velocity and cardiac output at different tidal volume targets of HFO&VTV.

Methods

This randomise

SUBMITTER: Kaltsogianni O 

PROVIDER: S-EPMC12542444 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature