Effects of sodium-glucose co-transporter-2 inhibitors on the risk of nephrolithiasis and urinary tract infections in Thai patients with type 2 diabetes: a hospital-based cohort study.

ABSTRACT:

Background

Nephrolithiasis is a multifactorial disease with many contributing factors varying across races, ethnicities, and sociocultural backgrounds. Diabetes is a significant independent risk factor for nephrolithiasis. We aimed to investigate the association between sodium-glucose co-transporter-2 inhibitors (SGLT2is) and the risk of nephrolithiasis in Thai patients with type 2 diabetes (T2D).

Methods

This retrospective cohort study of T2D patients used real-world data from Ramathibodi Hospital, Bangkok, Thailand. Adult T2D patients aged 18 years or older who had received SGLT2is, dipeptidyl peptidase 4 inhibitors (DPP4is), sulfonylureas (SUs), or thiazolidinediones (TZDs) were included. Inverse probability weighting with regression adjustment and Cox proportional hazard

SUBMITTER: Lukkunaprasit T 

PROVIDER: S-EPMC12542451 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature