The small bacterial membrane protein YohP induces nucleoid condensation in <i>E. coli</i> and inhibits oligomerization of antimicrobial peptides.

ABSTRACT: Prokaryotic organisms execute multiple stress response mechanisms in order to cope with rapidly changing environments. Some mechanisms respond to specific cues, such as the OxyR-dependent response to hydrogen peroxide or the SOS-response that is induced upon DNA-damage. These specific responses complement general mechanisms that respond to multiple and diverse stressors. One example is nucleoid condensation, which is a rapid and effective mechanism for genome protection and observed in response to various stresses, including entry into stationary phase. Recently, the upregulation of small membrane proteins (SMPs) in response to stress was observed, but details on how this emerging class of proteins modulate the stress response is largely unknown. Here, we demonstrate that the production of

SUBMITTER: Natriashvili A 

PROVIDER: S-EPMC12542507 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature