Ten-year outcomes of antiretroviral therapy: a retrospective cohort study in Tshwane district, South Africa.

ABSTRACT:

Background

South Africa continues to face one of the world's highest HIV burdens, with 7.7 million people living with HIV (PLWHIV) in 2023. Despite progress toward UNAIDS 95-95-95 targets, challenges in long-term retention and treatment outcomes persist. This study aimed to evaluate 10-year antiretroviral therapy (ART) outcomes among PLWHIV initiated on treatment in 2013 within Tshwane District, South Africa.

Methods

Retrospective cohort using Tier.Net data from 1,337 adults across 10 randomly selected facilities (clinics and community health centres [CHCs]). Outcomes were retention, loss to follow‑up (LTFU), mortality, viral suppression, and CD4 recovery. We used Kaplan-Meier methods and multivariable models (Cox for LTFU and mortality, logistic for viral suppression, linea

SUBMITTER: Mhlongo K 

PROVIDER: S-EPMC12542511 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature