Redox reactivities of membrane-bound amyloid-β-Cu complexes and their targeting by metallothionein-3.

ABSTRACT: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ_1-40/42) in the central nervous system (CNS). Copper coordination to Aβ triggers Aβ_1-40/42 aggregation and promotes the catalytic generation of reactive oxygen species (ROS). Due to its amphiphilic nature, Aβ_1-40/42 can interact with cell membranes and compromise their integrity. In this work, we characterized the insertion of Aβ_1-42 into an artificial lipid bilayer system mimicking cell membranes and demonstrate that the Aβ_1-42-lipid interaction does not prevent the Cu²⁺ coordination to Aβ_1-42. We performed a comparative analysis of the redox reactivities of membrane-bound Aβ_1-42 (memAβ_1-42-Cu²⁺)

SUBMITTER: Perez-Medina L 

PROVIDER: S-EPMC12542617 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature