Effects of simulated microgravity on biological features and virulence of the fungal pathogen <i>Cryptococcus neoformans</i>.

ABSTRACT: Cryptococcus neoformans is a fungal pathogen that causes cryptococcal meningitis, mainly in immunocompromised individuals, such as those with HIV. Its recent detection on the International Space Station raises concerns about potential health risks in space, where immune systems may be compromised. However, its behavior in space-like conditions remains unclear. In this study, we examined the effects of simulated microgravity on C. neoformans. We found that the condition enhanced the fungus's resistance to membrane and osmotic stress and increased key virulence factors, including capsule formation, melanin production, and urease activity. Using Caenorhabditis elegans as a host model, infections under simulated microgravity were more pathogenic. These findings highlight t

SUBMITTER: Phetruen T 

PROVIDER: S-EPMC12542639 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature