Region-specific genomic variation and functional divergence of <i>Helicobacter pylori</i> clinical isolates from the gastric antrum and corpus.

ABSTRACT: The genetic variability of Helicobacter pylori contributes to differences in the severity of gastrointestinal diseases. Within the stomach, H. pylori exhibits diverse strain patterns and genetic variations that enable the evolution of new virulence factors, development of antibiotic resistance, and evasion of the host immune system. However, the comprehensive analysis of whole-genome sequences and their functional impact on gastric epithelial cells remains limited. In this study, we performed whole-genome sequencing, de novo assembly, and comparative genomic analysis on two pairs of H. pylori strains (v225/v226 and v290/v291) isolated from the antrum and corpus of two peptic ulcer patients. Bioinformatic tools were used to annotate and compare genes related to a

SUBMITTER: Lai C-H 

PROVIDER: S-EPMC12542646 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature