Transcriptomic profiling of <i>Debaryomyces hansenii</i> reveals detoxification and stress responses to benzo(a)pyrene exposure.

ABSTRACT: The environmental accumulation of polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), poses significant threats to ecosystems and public health due to their persistent nature, mutagenic potential, and well-documented carcinogenicity. In this study, we investigated the ability of the extremophilic yeast Debaryomyces hansenii to activate specialized detoxification mechanisms for BaP degradation, even under nutrient-deprived conditions. When exposed to 100 ppm BaP, D. hansenii eliminated over 70% of the contaminant within 3 days, while maintaining normal growth dynamics. RNA-Seq analysis revealed widespread transcriptional remodeling, with 1,179 genes upregulated and 1,031 downregulated under BaP-only conditions, and 1,067 upregulated and 977 downregulated gen

SUBMITTER: Padilla-Garfias F 

PROVIDER: S-EPMC12542653 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature