Global phylogeography and genomic characterization of <i>bla</i>_NDM-1-positive clinical <i>Proteus mirabilis</i> isolates from China.

ABSTRACT: Carbapenem-resistant Proteus mirabilis (CRPM), largely driven by dissemination of bla_NDM-1, poses a growing global threat, yet its phylogeographic and genetic patterns remain understudied. We analyzed 16 bla_NDM-1-harboring CRPM clinical isolates from a tertiary hospital in China (2017-2024) using antimicrobial susceptibility testing, conjugation assays, whole-genome sequencing, and growth experiments. We found that bla_NDM-1 dissemination occurred primarily via plasmids and Salmonella Genomic Island 1 (SGI1), including a novel SGI1-PM16 variant. Early transmission events were associated with Tn125-derived elements (ΔTn125), while ISCR1 appeared to mediate rolling-circle transposition and likely facilitated loc

SUBMITTER: Guo J 

PROVIDER: S-EPMC12542671 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature