Pleiotropic role of PAX cyclolipopeptides in the <i>Xenorhabdus</i> bacterium mutualistically associated with entomopathogenic nematodes.

ABSTRACT: Xenorhabdus is an entomopathogenic bacterium involved in a mutualistic relationship with Steinernema nematodes. Xenorhabdus produces a multitude of specialized metabolites by non-ribosomal peptide synthetase (NRPS) pathways to mediate bacterium-nematode-insect interactions. PAX cyclolipopeptides are a family of NRP-type molecules whose ecological role remains poorly understood. In this study, the pleiotropic role of PAX peptides in the life cycle of Xenorhabdus nematophila has been investigated. By mass spectrometry analysis, we first demonstrated that PAX peptides were detected from the pathogenic stage up to the necrotrophic stage. We discovered that the bromothymol blue adsorption phenotype historically used to discriminate Xenorhabdus variants was ass

SUBMITTER: Claveyroles N 

PROVIDER: S-EPMC12542672 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature