Multi-cohort analysis unveils novel microbial targets for the treatment of hyperuricemia and gout.

ABSTRACT: The gut microbiota plays a crucial role in the development of hyperuricemia (HUA) and gout. However, the variability in study designs and analytical methods has led to inconsistent conclusions across different studies. Here, we conducted a comprehensive analysis of the gut microbiota associated with HUA and gout by examining 368 16S rRNA sequencing data from four Chinese cohorts, including 159 healthy controls (HC), 136 HUA patients, and 73 gout patients. Our findings indicate that there were significant differences in the gut microbiota composition between the three groups. Specifically, the HUA and gout groups demonstrated an increased abundance of pro-inflammatory bacteria, such as Fusobacterium and Bilophila, while beneficial bacteria known for their anti-inflammatory pro

SUBMITTER: Qie J 

PROVIDER: S-EPMC12542679 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature