Comparative analysis of colonization and survival strategies of regionally predominant LA-MRSA clones ST398 and ST9.

ABSTRACT: Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) displays distinct geographical distribution patterns, with ST398 predominating in Europe and ST9 being the dominant lineage in Asia, particularly China. However, the mechanisms underlying these differences remain poorly understood. In this study, we evaluated the cell adhesion capacity, anti-phagocytic properties, and porcine nasal colonization potential of ST9 and ST398 strains isolated from China and Germany. Colonization dynamics and characteristics were further explored using 16S rRNA gene sequencing and metatranscriptomic analysis. Our findings revealed that LA-MRSA ST398 strains exhibited superior colonization capabilities, including enhanced cell adhesion, increased resistance to macrophage-mediated ki

SUBMITTER: Ji X 

PROVIDER: S-EPMC12542691 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature