Stringent response-mediated ferroptosis-like death resistance underlies <i>Novosphingobium</i> persistence during ciprofloxacin stress.

ABSTRACT: Antibiotics, as emerging hazardous materials in the environment, pose significant risks to ecosystems and contribute to the spread of antibiotic-resistant bacteria. Although extensive knowledge has been accumulated on antibiotic-resistance mechanisms in individual bacteria, less is understood about how the bacterial communities respond to antibiotic exposure under natural environmental conditions, where nutrient supplies are often limited and fluctuating. Here, we report that Novosphingobium dominated in a wetland bacterial community under 1 µg/mL ciprofloxacin (CIP) exposure and persisted during DL-serine hydroxamate-induced starvation, where the stringent response alarmer (p)ppGpp was detected. Metagenome sequencing revealed that genes associated with siderophore transport, cytoch

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12542694 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature