Global wastewater microbiome reveals core bacterial community and viral diversity with regional antibiotic resistance patterns.

ABSTRACT: Municipal wastewater treatment plants (WWTPs) serve as global repositories for diverse and dynamic microbial communities, reflecting the complex interplay of human activities, environmental conditions, and public health challenges. Despite their importance, a comprehensive understanding of the global distribution, composition, and functional roles of these microbial ecosystems has remained elusive. Here, we present a comprehensive analysis of bacterial and viral diversities in global wastewater systems by examining 575 sampling sites across 74 cities in 60 countries. Through metagenomic analysis, we reconstructed 12,758 non-redundant bacterial metagenome-assembled genomes (MAGs) spanning 70 phyla, with 4,499 MAGs representing novel species. Despite considerable regional variation, we ident

SUBMITTER: Yan Y 

PROVIDER: S-EPMC12542734 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature