Gut microbiome mediates the associations between lifestyle factors and risk of colorectal high-risk adenoma: results from a population-based cohort study.

ABSTRACT: Lifestyle factors exert influence on the risk of colorectal cancer (CRC) and its precursors. However, the interaction between gut microbiota and lifestyle factors concerning colorectal high-risk adenomas (HRAs), as well as the specific microbial taxa implicated, remains underexplored. Here, we aimed to investigate the impact of common lifestyle factors on HRAs and to explore the potential mediating roles of gut microbiota in these effects. A total of 3,827 participants were enrolled from our multicenter CRC screening cohort. Lifestyle factors over the 12 months preceding enrollment were assessed via questionnaires. Fecal samples were collected upon enrollment and analyzed using 16S rRNA sequencing. Multivariate analyses were used to identify lifestyle-related risk factors for HRA, followed

SUBMITTER: Song K 

PROVIDER: S-EPMC12542775 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature