Understanding the complex interplay between tau, amyloid and the network in the spatiotemporal progression of Alzheimer's disease.

ABSTRACT:

Introduction

The interaction of amyloid and tau in neurodegenerative diseases is a central feature of AD pathophysiology. While experimental studies point to various interaction mechanisms, their causal direction and mode (local, remote or network-mediated) remain unknown in human subjects. The aim of this study was to compare mathematical reaction-diffusion models encoding distinct cross-species couplings to identify which interactions were key to model success.

Methods

We tested competing mathematical models of network spread, aggregation, and amyloid-tau interactions on publicly available data from ADNI.

Results

Although network spread models captured the spatiotemporal evolution of tau and amyloid in human subjects, the model including a one-way amyloid-to-tau agg

SUBMITTER: Raj A 

PROVIDER: S-EPMC12542852 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature