Contribution of HIV transmission bursts to future HIV infections.

ABSTRACT:

Objective

To estimate the influence of bursts of rapid HIV transmission on future transmission and describe populations affected by transmission bursts.

Design

Phylogenetic analysis of US National HIV Surveillance System data.

Methods

Time-scaled phylogenetic trees were inferred for six geographic regions using sequences from persons with HIV (PWH) with diagnoses of HIV infection 2014-2019. Transmission bursts were defined as at least three adjacent inferred transmission events in the phylogeny during a detection period. We calculated the relative contribution of transmission bursts 2015-2016 to transmission 2017-2019 compared with nonbursts. Then, we detected bursts within any sliding 2-year period 2014-2019 and assessed descriptive associations of characteristics of

SUBMITTER: Billock RM 

PROVIDER: S-EPMC12542871 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature