Modifiable lifestyle and metabolic risk factors for colorectal polyps: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate associations between unhealthy lifestyles, metabolic diseases, and colorectal polyps, with emphasis on subtype-specific effects.

Methods

We systematically searched PubMed, Embase, Cochrane Library, and SinoMed (up to July 2024) for studies reporting odds ratios (ORs) of colorectal polyps associated with lifestyle or metabolic factors. Heterogeneity was quantified using I (2) statistics, with random-effects models applied as the primary analytical approach. Subgroup analyses were conducted to investigate potential effect modifiers, and meta-regression was performed to explore continuous sources of heterogeneity, while sensitivity analyses and funnel plots evaluated robustness and bias.

Results

Alcohol (OR = 1.63, 95%CI:1.48-1.78), high-fat diet (O

SUBMITTER: Lei Y 

PROVIDER: S-EPMC12542907 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature