A dynamic gene regulatory code drives synaptic development of hippocampal granule cells.

ABSTRACT: Connecting neurons into functional circuits requires the formation, maturation, and plasticity of synapses. While advances have been made in identifying individual genes regulating synapse development, the molecular programs orchestrating their action during circuit integration of neurons remain poorly understood. Here, we take a multiomic approach to reconstruct gene regulatory networks (GRNs), comprising transcription factors (TFs), regulatory regions, and predicted target genes, in hippocampal granule cells (GCs). We find a dynamic gene regulatory code, with early and late postnatal GRNs regulating cell morphogenesis and synapse organization and plasticity, respectively. Our results predict sequential regulations, with early-active TFs delaying the activation of later GRNs and their put

SUBMITTER: Lorente-Echeverria B 

PROVIDER: S-EPMC12542959 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature