Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.

ABSTRACT: Intracranial aneurysms (IAs) affect about 3% of the population, often leading to catastrophic outcomes upon rupture. Vasa vasorum, microvessels supplying arterial walls, are conjectured to induce inflammation and leakage in IAs that drive adverse remodeling. Using scanning immunofluorescent multiphoton imaging and micro-computed tomography to visualize intact IA specimens, we identified an extensive vasa vasorum plexus in the IA wall. Our quantitative analyses show significant colocalization of vasa vasorum with calcifications, a strong correlation with increased wall thickness (R² = 0.96, P < 0.001), and associations with well-defined multiaxially oriented collagen fibers. These findings highlight a more nuanced role for vasa vasorum, suggesting both adverse and p

SUBMITTER: Abdurakhmonov M 

PROVIDER: S-EPMC12542963 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature