A multifunctional injectable ε-poly-L-lysine-loaded sodium-alginate/gelatin hydrogel promotes the healing of infected wounds by regulating macrophage polarization and the skin microbiota.

ABSTRACT:

Background

Infected wounds caused by bacteria such as Escherichia coli and Staphylococcus aureus pose significant challenges during the healing process. Hydrogels have emerged as promising materials for the treatment of such infections, as they have the potential to deliver therapeutic agents while supporting tissue repair. This study aimed to develop ε-PLL@SA/Gel (PSG) hydrogels by incorporating varying concentrations of ε-poly-L-lysine (ε-PLL) into sodium alginate/gelatin (SA/Gel) using calcium chloride as a crosslinking agent, and to evaluate their antibacterial efficacy.

Methods

The mechanical properties, biocompatibility, antibacterial activity of hydrogels were evaluated. Biocompatibility was examined by measuring cell viability and proliferation of human

SUBMITTER: Zu X 

PROVIDER: S-EPMC12542974 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature