Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation.

ABSTRACT:

Background

Low wall shear stress (WSS) at arterial bifurcations and curves damages endothelial cells, promoting the development of atherosclerosis. Although the accumulation of iron in plaques has been observed, the mechanisms behind it and its effects are not fully understood.

Methods

Detect the iron content in different parts of the mouse partial carotid artery ligation model and the aorta. The chelating iron therapy was used to assess the impact of low WSS-induced iron accumulation and atherosclerosis in the arterial wall. In vitro experiments utilized human umbilical vein endothelial cells and an orbital-shaker model to simulate WSS. Mice with endothelial cell-specific knockout of IRP2 (iron regulatory protein 2) and deletion of Apoe (Apolipoprotein e; Apoe

SUBMITTER: Zheng L 

PROVIDER: S-EPMC12542997 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature