Macrophage DNases Limit Neutrophil Extracellular Trap-Mediated Defective Efferocytosis in Atherosclerosis.

ABSTRACT:

Background

Neutrophil extracellular traps (NETs) contribute to atherosclerosis progression and are linked to adverse clinical outcomes such as myocardial infarction and stroke. Although the triggers of NET formation in plaques are known, the mechanisms governing DNase-mediated NET clearance and how these are disrupted during atherosclerosis remain unclear. Moreover, the consequences of impaired NET clearance on disease progression are not known.

Methods

Low-density lipoprotein receptor knockout (Ldlr^-/-) mice with hematopoietic cell-specific deletion of DNase1 and DNase1L3 were fed a Western-type diet for 16 weeks to examine the impact of loss of DNase activity and the subsequent NET accumulation on advanced atherosclerosis. The eff

SUBMITTER: Dhawan UK 

PROVIDER: S-EPMC12542999 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature