Afucosylation of anti-dengue IgG is associated with enhanced susceptibility to dengue virus infection postvaccination.

ABSTRACT: Dengue viruses (DENVs) cause 390 million infections annually, although only ~25% of these infections are symptomatic. Whereas antibody features linked to severe DENV disease are well studied, factors influencing infection susceptibility remain less clear. Here, we examined immunoglobulin G (IgG) characteristics before and after DENV vaccination (Dengvaxia) in individuals with a history of prior DENV exposure, comparing those who developed postvaccination infections to those who remained infection free. Elevated anti-DENV afucosylation, present before or after vaccination, was associated with increased likelihood of infection after vaccination. These data were further supported by mechanistic studies, which revealed that nonneutralizing, afucosylated, post-Dengvaxia IgG enhanced DENV replic

SUBMITTER: Ashraf U 

PROVIDER: S-EPMC12543083 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature