Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway.

ABSTRACT: Inflammatory bowel disease often complicates intestinal lumen stenosis, and intestinal fibrosis is the core pathological process leading to its development. Currently, there are no effective drug treatments available to prevent or improve intestinal fibrosis. Previous studies have shown that PAM (plasma-activated media) inhibits epithelial-mesenchymal transition (EMT) and improves skin fibrosis by regulating the PPARγ/TGF-β1 axis. However, it is unclear whether PAM can improve intestinal fibrosis. We used a gradient concentration of PAM to intervene in the dextran sulfate sodium (DSS)-induced mouse intestinal fibrosis model to evaluate its effects onalleviating fibrosis and explore the specific molecular mechanisms. In addition, we used PAM to intervene in the TGF-β1-induced rat intestinal

SUBMITTER: You Y 

PROVIDER: S-EPMC12543144 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature