Unveiling immunity dynamics: Serological characteristics of antibodies against Japanese encephalitis virus in Guangdong, China.

ABSTRACT:

Background

Defining the immune dynamics of Japanese encephalitis (JE) in healthy individuals is crucial for assessing population susceptibility and evaluating the effectiveness of vaccinations.

Methods

We conducted a cross-sectional serological survey of anti-JEV IgG antibodies and anti-JEV neutralizing antibodies (nAbs) in Guangzhou City, Zhanjiang City and Heyuan City of Guangdong Province, China.

Results

A total of 691 participants were included from 2018-2022, among whom 50 were dengue IgG antibody positive and 641 were dengue IgG antibody negative. In the total population, the anti-JEV IgG antibody positivity rate detected by enzyme-linked immunosorbent assay (ELISA) was 51.37% (95% CI: 47.64-55.11%), and the neutralizing antibody positivity rate detected using t

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12543178 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature