Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study.

ABSTRACT:

Background

Exposure to environmental pollutants has been associated with obesogenic effects, yet evidence in young children remains sparse. Parabens, widely used as antimicrobial preservatives in personal care products, may disrupt satiety hormones during early life, potentially influencing long-term metabolism and weight regulation.

Methods

This cross-sectional study analyzed urinary methyl, ethyl, propyl, and butylparaben (MeP, EtP, PrP, BuP) levels in 4-6-year-old children from the ENVIRONAGE birth cohort using ultra-performance liquid chromatography/tandem mass spectrometry. Plasma satiety hormones (leptin, pancreatic polypeptide, glucagon-like peptide 1, and peptide YY) were measured via (radio-)immunoassays. Associations were assessed in 188 samples using covariate-adj

SUBMITTER: Reimann B 

PROVIDER: S-EPMC12543222 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature