Plasma Metabolites of One-Carbon Metabolism Are Associated With Esophageal Adenocarcinoma in a Population-Based Study.

ABSTRACT:

Introduction

Esophageal adenocarcinoma (EAC) develops through histopathological stages, including Barrett's esophagus (BE). We analyzed the associations between plasma levels of one-carbon metabolism factors and risks of long-segment BE or EAC.

Methods

Plasma levels were measured from an Irish population-based case-control study (Factors INfluencing the Barrett Adenocarcinoma Relationship study; 204 long-segment BE cases, 211 EAC cases, and 251 controls). A "methyl replete score" was derived by assigning a score of 0 (median) to the levels of 3 dietary methyl donors (methionine, choline, and betaine) and summing across the metabolites. Multinomial logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the ass

SUBMITTER: Shah SC 

PROVIDER: S-EPMC12543241 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature