Liver biopsies obtained throughout SIV infection reveal evolving interferon stimulated protein expression within distinct monocyte/macrophage subsets.

ABSTRACT: Liver dysfunction is more common and more severe among people with HIV than in the general population. Our previous transcriptomic analysis identified an increased hepatic type-1 interferon (IFN-1) response in simian immunodeficiency virus (SIV) infected rhesus macaques, including pronounced upregulation of the IFN-1 stimulated gene product MX1. Here, we interrogated the role of different cell types in the IFN-1 response, focusing on macrophage subsets. During the acute phase of SIV infection, the expression of MX1 in liver biopsies was elevated in the resident macrophage Kupffer cells (KCs, CD163 + CD206+) as well as liver sinusoidal endothelial cells (LSECs, CD163- CD206+). Chronic infection was associated with increased MX1 expression both within KCs and the recruited monocyte-derived m

SUBMITTER: Derby N 

PROVIDER: S-EPMC12543282 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature