Structure-function coupling using fixel-based analysis and functional magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment.

ABSTRACT: Functional MRI (fMRI) and diffusion-weighted imaging (DWI) help explore correlations between structural connectivity (SC) and functional connectivity (FC; SC-FC coupling). Studies on mild cognitive impairment (MCI) and Alzheimer's disease (AD) observed coupling disruptions, co-occurring with cognitive decline. Advanced "fixel-based" analyses improved DWI's accuracy in assessing microstructural and macrostructural features of white matter (WM), but previous aging coupling studies commonly defined SC via tensor-based tractography and streamline counts, thereby missing fiber-specific information. We investigated different types of fixel-FC coupling and their relation to cognition in 392 participants (Age_mean = 73; 207 females) from the ADNI. Two hundred twenty-five controls, 142 MC

SUBMITTER: Billaud CHA 

PROVIDER: S-EPMC12543303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature