Appendectomy Is Not Associated With a Milder Clinical Course of Ulcerative Colitis: A Nationwide Danish Population-Based Study.

ABSTRACT:

Background

Appendectomy may have a beneficial effect on the course of ulcerative colitis (UC), but the association remains debated.

Aim

To examine if appendectomy influences the clinical course of UC.

Methods

We identified all patients diagnosed with UC in Denmark from 1977 to 2017 from the Danish National Patient Registry. Patients who underwent appendectomy were matched for age, sex, calendar year and disease duration with up to 10 comparators with UC and no appendectomy. We compared UC-related admission rates, rates of initiating treatment with biologics, and colorectal resection rates between patients with UC with and without appendectomy.

Results

22,098 patients with UC (2014 with and 20,084 without appendectomy) were followed for a median 10.3 years (inte

SUBMITTER: Mark-Christensen A 

PROVIDER: S-EPMC12543334 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature