Development and Validation of a Tool to Predict Onset of Mild Cognitive Impairment and Alzheimer Dementia.

ABSTRACT:

Importance

The ability to predict the onset of mild cognitive impairment (MCI) and Alzheimer dementia (AD) could allow older adults and clinicians to make informed decisions about dementia care.

Objective

To assess whether the age at onset of MCI and AD can be predicted using a statistical modeling approach.

Design, setting, and participants

This prognostic study used data from 2 aging and dementia cohort studies-the Australian Imaging, Biomarker and Lifestyle (AIBL) study and the Alzheimer's Disease Neuroimaging Initiative (ADNI)-for model development and validation of the Florey Dementia Index (FDI), a tool used to predict the age at onset of MCI and AD in older adults. Data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer (A4) study were used for a simulat

SUBMITTER: Chu C 

PROVIDER: S-EPMC12543407 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature