Dietary modulation of gut microbiota and its role in atopic dermatitis: integrative evidence from animal and human studies.

ABSTRACT:

Background

Atopic dermatitis (AD) is associated with disturbance in the gut microbiota, but the dietary factors behind this dysbiosis are still unknown. Therefore, we investigated how food choice patterns impact the gut microbiota, which in turn influences the development and progression of AD.

Methods

A mice AD model washed using 2,4-dinitrochlorobenzene (DNCB). After 4 weeks, epidermal histopathology, serum immunoglobulin E (IgE) levels, and gut microbiota profiles were assessed. At the same time, we recruited 102 clinically diagnosed AD patients and 102 age- and sex-matched controls. Participants completed a food frequency questionnaire and provided stool samples to analyze dietary patterns, gut microbiota diversity, composition, function, and their associations.

Resul

SUBMITTER: Xu F 

PROVIDER: S-EPMC12545045 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature