Association between white matter structural damage and cognitive impairment in patients with cerebral small vessel disease based on TBSS technology.

ABSTRACT:

Objective

Cognitive impairment in patients with cerebral small vessel disease (CSVD) is closely associated with white matter injury. This study aims to evaluate whether diffusion tensor imaging (DTI) metrics can predict the risk of cognitive impairment in CSVD patients.

Methods

We retrospectively analyzed data from 54 CSVD patients, classified into a cognitive impairment group (CI, n = 25) and a non-cognitive impairment group (NCI, n = 29). Using tract-based spatial statistics (TBSS), we computed fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) across 48 major white matter tracts. Significant DTI metrics identified by univariate logistic regression were used to construct a multivariate logistic regression mo

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC12545093 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature