Utility of continuous glucose monitoring for identifying silent hypoglycemia in fructose-1,6-bisphosphatase deficiency: a pilot prospective evaluation.

ABSTRACT:

Background and objective

Fructose-1,6-bisphosphatase (FBPase) deficiency is a rare gluconeogenic disorder characterized by hypoglycemia, lactic acidosis, hyperuricemia, and ketosis, triggered by fasting or infection. Although dietary management aims to prevent hypoglycemia, accurate tools to monitor asymptomatic episodes are lacking. Continuous glucose monitoring (CGM) has not been systematically evaluated in FBPase deficiency. This study aimed to assess the utility of CGM in detecting silent hypoglycemia and its relationship with dietary management.

Methods

Ten genetically confirmed patients underwent blinded CGM using the Medtronic iPro2™ system. CGM metrics included time below range (TBR <70 mg/dL [<3.9 mmol/L]), time in range (TIR 70-150 mg/dL [3.9-8.3 mmol/L]), and time

SUBMITTER: Goksoy E 

PROVIDER: S-EPMC12545126 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature