Forced intensity-controlled endurance training on a small-animal treadmill machine inducing murine cardiac hypertrophy: insights and comparison to voluntary running models.

ABSTRACT: Endurance training is associated with decreased cardiovascular-related morbidity and mortality. Cardiac hypertrophy is an adaptive mechanism, and murine exercise models for cardiac hypertrophy are still under discussion. Using a small-animal treadmill, a forced intensity-controlled training model was conducted to characterize cardiac hypertrophy in mice utilizing multimodal analyses and then compared to datasets of voluntary running mice. Wild-type male C57BL/6 mice at 8 weeks old were subjected to forced endurance training using a small-animal treadmill or sedentary age-matched control. Five different measurement points (0-, 2-, 4-, 8-, and 12 weeks) were used to assess phenotypic changes. Each training group was scanned using an ECG-gated ¹⁸F-FDG PET/CT scan to evaluate cardia

SUBMITTER: Fischer M 

PROVIDER: S-EPMC12545138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature