Acute Kidney Injury Diagnostic Accuracy and Implications of Different Baseline Creatinine Equations.

ABSTRACT:

Introduction

Acute kidney injury (AKI) definitions rely on known baseline serum creatinine (Cr_b), unavailable in up to 75% of hospitalized children. New equations (the AKI Baseline Creatinine [ABC] methods) for estimating Cr_b were derived from children without kidney disease. We aimed to externally validate ABC methods in an international cohort and assess how different Cr_b equations alter AKI epidemiology.

Methods

AWARE was a prospective international study of critically ill children (aged 0-25 years) from 32 pediatric intensive care units (ICUs). A subset of AWARE (n = 2451) with known Cr_b (gold standard) was used to validate ABC methods using statistical measures of precision (R²) and accuracy (within 10% or 30

SUBMITTER: Bjornstad EC 

PROVIDER: S-EPMC12545555 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature