Longitudinal Estimated GFR Trajectories Among Workers at High Risk for CKD of Unknown Etiology.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) of unknown etiology is a leading cause of mortality among young men in Nicaragua and El Salvador, but longitudinal trends in kidney health and disease incidence remain poorly characterized.

Methods

We estimated glomerular filtration rate (eGFR) among young adult male workers in Nicaragua and El Salvador without known CKD (n = 569), aged 18 to 45 years, with follow-up every 6 months for 3 years. We estimated cumulative incidence of CKD, defined as ≥ 2 eGFR measurements < 60 ml/min per 1.73 m², and incidence rate in person-years. We used a hierarchical clustering approach to identify latent patterns in longitudinal eGFR.

Results

Cumulative incidence was 4.5% (n = 24). Incidence rate was 22.2 cases per 10

SUBMITTER: Leibler JH 

PROVIDER: S-EPMC12545559 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature