Klotho's Impact on Cardiovascular Disease, Fractures, and Mortality in Hemodialysis.

ABSTRACT:

Introduction

Klotho, an aging-suppressor protein, has been shown to promote cardiovascular and bone health in animal models of chronic kidney disease (CKD). However, limited data exist on its role in clinical outcomes among patients undergoing hemodialysis. This study aimed to investigate the association between soluble Klotho (sKlotho) levels and cardiovascular disease (CVD) events, fractures, and all-cause mortality in this population.

Methods

We enrolled 1241 patients on hemodialysis from multiple medical institutions, with a median follow-up of 39 months. The primary outcome was a composite of CVD events, fractures, and all-cause mortality.

Results

The median sKlotho concentration was 325.6 pg/ml (interquartile range [IQR]: 248.9-434.4 pg/ml). During the follow-up

SUBMITTER: Nakashima A 

PROVIDER: S-EPMC12545757 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature