Urinary Dickkopf-3 Predicts GFR Loss in the General Population.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) affects > 800 million people globally, with prevalence expected to increase, emphasizing the need for effective early detection and management strategies. Urinary Dickkopf-3 (uDKK3), a profibrotic glycoprotein from renal tubular cells, has been linked to acute kidney injury (AKI) and CKD progression. This study assesses uDKK3 as a biomarker for predicting glomerular filtration rate (GFR) decline in the general population.

Methods

We conducted a prospective cohort study with 1316 participants aged 55 to 69 years from the Renal Iohexol Clearance Survey (RENIS) (2014-2015), undergoing 1 to 3 GFR measurements using iohexol clearance over 5.3 years. uDKK3 levels were normalized to creatinine (Cr), categorizing participants by uDKK3/Cr lev

SUBMITTER: Norvik JV 

PROVIDER: S-EPMC12545817 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature