Hypothermia after Cardiac Arrest in Large Animals (HACA-LA): a randomized controlled experimental study.

ABSTRACT:

Background

Induced hypothermia after cardiac arrest is neuroprotective in several animal models of cardiac arrest, but few high-quality studies have been conducted in larger animals. Recent clinical trials have questioned the beneficial effects of post-ischemic hypothermia. This study investigated whether immediate cooling or a 2-h delay in cooling to 33 °C after cardiac arrest was neuroprotective compared to controlled normothermia in large animals.

Methods

Young adult female swine were anesthetized and kept at normothermia (38 °C). All animals were subject to 10 min of cardiac arrest by ventricular fibrillation, followed by 4 min of cardiopulmonary resuscitation, before the first countershock. At 10 min of return of spontaneous circulation (ROSC), animals were included and

SUBMITTER: Persson O 

PROVIDER: S-EPMC12545941 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature