Peripheral blood, lung and brain gene signatures in recovered and deceased patients with COVID-19.

ABSTRACT: COVID-19 is a multi-system disease that affects not only the respiratory system but also the neurological, hematological, and immune cells and tissues. The understanding of how the virus infiltrates and impacts a diverse set of human cells is still incomplete. This work examined bulk RNA-seq data from recovered COVID-19 patients (COVID-19 survivors with or without post-acute complications) to uncover the persisting perturbations in biological pathways. The investigation also analyzed the transcriptomic signatures in the lungs and brain tissues of deceased patients during the acute phase of infection to understand COVID-19 impact on these organs. In recovered COVID-19 patients, the severity of acute COVID-19 influenced the subsequent disturbance of gene expression patterns in the post-acute

SUBMITTER: Twum E 

PROVIDER: S-EPMC12545983 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature