A multisite study of the overlap between symptoms and cognition in schizophrenia: Une etude multicentrique sur le chevauchement entre les symptomes et les troubles cognitifs chez les personnes atteintes de schizophrenie.

ABSTRACT: ObjectiveCognitive impairment is a core feature of schizophrenia spectrum disorders. Our previous study on a first-episode psychosis cohort showed that symptoms related to impoverished/disorganized communication and motor impoverishment predicted verbal and working memory scores, respectively. This study aimed to explore those predictors in people across the range of illness chronicity.MethodsWe employed iterative Constrained Principal Component Analysis (iCPCA) to investigate the relationship between 15 cognitive measures from the MATRICS battery, including processing speed, attention, working, verbal and nonverbal memory, reasoning, and problem-solving, and 27 Positive and Negative Syndrome Scale (PANSS) items in 198 outpatients from two sites in Australia and one in Canada. The iCPCA me

SUBMITTER: Skiba RM 

PROVIDER: S-EPMC12546101 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature