Effects of permissive hypercapnia on intraoperative cerebral oxygenation and early postoperative cognitive function in elderly patients undergoing laparoscopic surgery.

ABSTRACT:

Background

This study examines the effect of permissive hypercapnia (PH) on cerebral oxygenation (rSO₂) and early postoperative cognitive function in elderly patients (EP) undergoing laparoscopic surgery (LS).

Methods

This retrospective study analyzed data from elderly patients who underwent laparoscopic surgery with PH mechanical ventilation or conventional ventilation (CV) ventilation strategies between 2019 and 2024. The individuals were separated into two groups as stated by the intraoperative anesthesia method, and equal numbers in each group. A total of 550 patients were initially screened for eligibility, of whom 100 were excluded based on predefined criteria. The final analysis included 450 patients, with 225 receiving PH mechanical ventilation (PH group)

SUBMITTER: Chen H 

PROVIDER: S-EPMC12546227 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature