Intra-adaptational changes in online adaptive radiotherapy: from the ideal to the real dose.

ABSTRACT:

Background and purpose

Online adaptive radiotherapy has demonstrated dosimetric benefits by accounting for interfractional organ variations. However, this study investigates the dosimetric impact of intra-adaptational anatomical changes that take place during the adaptation process.

Methods

Our retrospective analysis was conducted on 155 fractions from 8 prostate cancer patients treated with adaptive radiotherapy using the Varian Ethos system (Varian, Palo Alto, California, USA). Various dose-volume metrics for the targets and organs at risk were assessed for (1) the non-adapted (an original plan on a pretreatment cone-beam CT [CBCT], acquired at the beginning of a treatment session), (2) the adapted (an adapted plan on a pretreatment CBCT), and (3) the delivered dose distri

SUBMITTER: Malygina H 

PROVIDER: S-EPMC12546291 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature