A novel antibacterial approach: targeting methicillin-resistant Staphylococcus aureus with carvone nanoemulgel.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) remains a challenging issue in the treatment of diabetic wounds. The current researchinvestigates the formulation, antimicrobial, and wound healing efficacy of D-carvone-based nanoemulgel against clinical MRSA strains collected from diabetic wound infections. Nanoemulsion and nanoemulgel preparations for carvone were prepared and assessed. The antibacterial activity was assessed using both the cup method and microtiter assay, in addition to electron microscopy and molecular techniques. An excision wound model was used to evaluate the diabetic wound healing activity of NPs carvone. Diabetic rats, induced via streptozotocin (STZ, 65 mg/kg, i.p.), were separated into three groups: diabetic negative control, carvone, and NPs carvone groups, in

SUBMITTER: Soliman WE 

PROVIDER: S-EPMC12546319 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature