Dysregulation of melatonin rhythm in Parkinson's and Huntington's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Parkinson's disease (PD) and Huntington's disease (HD) are progressive neurodegenerative diseases with early non-motor symptoms, such as sleep disturbances, which often precede motor symptoms but are frequently overlooked. Although HD can be diagnosed genetically, PD lacks reliable biomarkers for its early detection. Melatonin, a circadian regulator, may be a promising early biomarker to address this issue.

Methods

A database search was performed to identify relevant studies. Meta-analyses were conducted using the ratio of means (RoM) as an effect size and I² as a heterogeneity test.

Results

Melatonin rhythmicity was significantly disrupted in both PD and HD groups. PD patients showed reduced amplitude [RoM = 0.76, 95% CI (0.26 to 1.26); p =</

SUBMITTER: Suram RP 

PROVIDER: S-EPMC12546346 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature